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Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

《医学前沿（英文）》 2008年 第2卷 第3期   页码 216-228 doi: 10.1007/s11684-008-0042-x

摘要： Wnt/?-catenin signaling pathway has been identified as a key cellular pathway in embryogenesis and disease, including cancers. In recent years, more and more interacting components have been observed and their exact functions approached, thus ensuring the most complicated understanding of this pathway in normal organism development and disorders. In hepatocellular carcinoma (HCC), with a deeply understanding of this pathway, more and more genes which contribute to aberrant activation of Wnt/?-catenin signaling pathway has recently been identified and their exact roles in HCC pursued. In this review, we will focus on a mostly updated understanding of this pathway and its observed role in HCC by emphasizing the gene defects identified to promote tumorigenesis and development.

关键词： interacting     complicated understanding     embryogenesis     activation     organism development    

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An analytical method for calculating torsional constants for arbitrary complicated thin-walled cross-sections

DU Baisong, GE Yaojun, ZHOU Zheng

《结构与土木工程前沿（英文）》 2007年 第1卷 第3期   页码 293-297 doi: 10.1007/s11709-007-0038-7

摘要： In this paper, an analytical method is proposed for calculating torsional constants for complicated thin-walled cross-sections with arbitrary closed or open rib stiffeners. This method uses the free torsional theory and the principle of virtual work to build governing equilibrium equations involving unknown shear flows and twisting rate. After changing the form of the equations and combining these two unknowns into one, torsional function, which is a function of shear flow, shear modulus, and twisting rate, is included in the governing equations as only one of the unknowns. All the torsional functions can be easily obtained from these homogeneous linear equations, and torsional constants can be easily obtained from the torsional functions. The advantage of this method is that we can easily and directly obtain torsional constants from the torsional functions, rather than the more sophisticated shear flow and twisting rate calculations. Finally, a complicated thin-walled cross-section is given as a valid numerical example to verify the analytical method, which is much more accurate and simpler than the traditional finite element method.

关键词： homogeneous     complicated thin-walled     numerical example     advantage     torsional function    

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Study of base friction simulation tests based on a complicated engineered bridge slope

Liu HE, Guang WU, Hua WANG

《结构与土木工程前沿（英文）》 2012年 第6卷 第4期   页码 393-397 doi: 10.1007/s11709-012-0174-6

摘要： In this paper, a physical base friction test model of a slope is established. The model is based on similarity principles and the geological conditions of a complicated bridge slope during construction, deformation and failure. The behavior of the slope in both its natural state and during excavation loading is qualitatively analyzed through base friction tests. The base friction test results are then subjected to comparison and analysis using finite element numerical simulation. The findings show that the whole engineered slope tends to stabilize in its natural state, whereas instabilities will arise at faulted rock masses located near bridge piers during excavation loading. Therefore, to ensure normal construction operation of bridge works, it is suggested that pre-reinforcement of faulted rock masses be performed.

关键词： base friction test     slope stability evaluation     bridge slope    

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The effect of orbital radiation therapy on thyroid-associated orbitopathy complicated with dysthyroid

null

《医学前沿（英文）》 2017年 第11卷 第3期   页码 359-364 doi: 10.1007/s11684-017-0528-5

摘要：

Thyroid-associated orbitopathy (TAO) is an inflammatory autoimmune disorder. The most serious complication of TAO is dysthyroid optic neuropathy (DON), which can lead to permanent vision loss because of volume expansion in the orbital apex. Orbital radiation therapy (ORT) is an anti-inflammatory treatment used in the treatment of active TAO. Clinical studies support radiotherapy as having a modest effect on DON, and early radiotherapy may protect against disease progression to DON. Current studies suggest that radiotherapy is generally safe. However, risks still exist in some cases. The possible effects of radiotherapy on TAO, especially complicated with DON, are reviewed. The effects of radiotherapy on DON are not completely known, and evidence from standardized, prospective, and multicenter clinical trials is still lacking.

关键词： thyroid-associated orbitopathy     dysthyroid optic neuropathy     orbital radiation therapy    

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From understanding to designing soundscapes

Jian KANG

《结构与土木工程前沿（英文）》 2010年 第4卷 第4期   页码 403-417 doi: 10.1007/s11709-010-0091-5

摘要： Soundscape represents a step change in the field of environmental acoustics in that it combines physical, social, and psychological approaches. Although the term soundscape was introduced in the 1960s, significant attention to it has mainly been paid in the last decade or so in the community of environmental acoustics by researchers and recently by practitioners including policy makers. This paper explores the current situation and future challenges in soundscape. Starting with a framework on research and practical needs in soundscape and a brief introduction of some recent/current networks, activities, projects, and publications, this paper then presents a systematic review of recent progress in soundscape research and practice. A short review of the soundscape research in China is also given.

关键词： soundscape     environment     sound     design     urban     landscape    

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整合矿井复杂通风系统的优化改造

张付涛

《中国工程科学》 2011年 第13卷 第11期   页码 68-71

摘要：

唐山沟煤矿作为资源整合矿井，存在通风系统复杂和安全隐患多等一系列问题，通过通风阻力测定、风机性能测试和通风系统合理可靠性评价，查找原有矿井通风系统存在的问题，分析其主要原因，提出了通风系统优化改造方案。经实施后，降低了通风系统阻力，提高了矿井通风系统稳定性和抗灾能力。

关键词： 整合矿井     复杂通风系统     优化改造    

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Air pollution complex: Understanding the sources, formation processes and health effects

Min Shao,Shuxiao Wang,Armistead G. Russell

《环境科学与工程前沿（英文）》 2016年 第10卷 第5期 doi: 10.1007/s11783-016-0883-5

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Fundamental frequency and testing mode of complicated elastic clamped-plate vibration

QI Hongyuan, GUAN Yiduo

《机械工程前沿（英文）》 2008年 第3卷 第4期   页码 360-364 doi: 10.1007/s11465-008-0084-4

摘要： Aimed at the modal analysis of complicated elastic clamped-plates, a trigonometric interpolation method of conformal mapping is applied to set up the mapping function between a complicated region and a unit dish region, and the fundamental frequency of the complicated vibrating region is analyzed with the help of the Galerkin method. Taking an elastic rectangle-plate with arc radius as an example, the testing mode frequency band of plates is determined by analyzing the fundamental frequency; meanwhile, according to hamming testing method of multi-point excitation to the single-point response, and by signal processing technology and its software programming, modal parameter recognition of the elastic clamped-plate is completed. Comparing the first order modal frequency with the theoretical fundament frequency, the validity of the testing mode method and theoretical analysis are verified.

关键词： multi-point excitation     rectangle-plate     single-point     processing technology     trigonometric interpolation    

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Atomistic understanding of interfacial processing mechanism of silicon in water environment: A ReaxFF

《机械工程前沿（英文）》 2021年 第16卷 第3期   页码 570-579 doi: 10.1007/s11465-021-0642-6

摘要： The interfacial wear between silicon and amorphous silica in water environment is critical in numerous applications. However, the understanding regarding the micro dynamic process is still unclear due to the limitations of apparatus. Herein, reactive force field simulations are utilized to study the interfacial process between silicon and amorphous silica in water environment, exploring the removal and damage mechanism caused by pressure, velocity, and humidity. Moreover, the reasons for high removal rate under high pressure and high velocity are elucidated from an atomic perspective. Simulation results show that the substrate is highly passivated under high humidity, and the passivation layer could alleviate the contact between the abrasive and the substrate, thus reducing the damage and wear. In addition to more Si-O-Si bridge bonds formed between the abrasive and the substrate, new removal pathways such as multibridge bonds and chain removal appear under high pressure, which cause higher removal rate and severer damage. At a higher velocity, the abrasive can induce extended tribochemical reactions and form more interfacial Si-O-Si bridge bonds, hence increasing removal rate. These results reveal the internal cause of the discrepancy in damage and removal rate under different conditions from an atomic level.

关键词： silicon     ReaxFF     molecular dynamics     friction     damage    

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Culturomics and metagenomics: In understanding of environmental resistome

Monika Nowrotek, Łukasz Jałowiecki, Monika Harnisz, Grażyna Anna Płaza

《环境科学与工程前沿（英文）》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1121-8

摘要：

State of the art of culturomics and metagenomics to study resistome was presented.

The combination of culturomics and metagenomics approaches was proposed.

The research directions of antibiotic resistance study has been suggested.

关键词： Culturomics     Metagenomics     Antibiotic resistance     Resistome    

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Effect of styrene-butadiene-styrene copolymer on the aging resistance of asphalt: An atomistic understanding

《结构与土木工程前沿（英文）》 2021年 第15卷 第5期   页码 1261-1276 doi: 10.1007/s11709-021-0761-5

摘要： To reveal the potential influence of styrene-butadiene-styrene (SBS) polymer modification on the anti-aging performance of asphalt, and its mechanism, we explored the aging characteristics of base asphalt and SBS-modified asphalt by reaction force field (ReaxFF) and classical molecular dynamics simulations. The results illustrate that the SBS asphalt is more susceptible to oxidative aging than the base asphalt under oxygen-deficient conditions due to the presence of unsaturated C=C bonds in the SBS polymer. In the case of sufficient oxygen, the SBS polymer inhibits the oxidation of asphalt by restraining the diffusion of asphalt molecules. Compared with the base asphalt, the SBS asphalt exhibits a higher degree of oxidation at the early stage of pavement service and a lower degree of oxidation in the long run. In addition, SBS polymer degrades into small blocks during aging, thus counteracting the hardening of aged asphalt and partially restoring its low-temperature cracking resistance.

关键词： SBS asphalt     oxidative aging     asphalt hardening     ReaxFF     molecular dynamics    

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Recent advances in understanding genetic variants associated with economically important traits in sheep

Song-Song XU, Meng-Hua LI

《农业科学与工程前沿（英文）》 2017年 第4卷 第3期   页码 279-288 doi: 10.15302/J-FASE-2017151

摘要： Sheep are one of the most economically important domesticated animals for human society. However, genetic improvements for the key traits associated with meat, growth, milk, wool, reproduction, horns and tails progress slowly using conventional crossbreeding methods. With the development and utilization of high-throughput screening technologies over the last decade, a list of functional genes and genetic variants associated with these traits has been identified. This review covers recent genome-wide studies on sheep productive traits using high-throughput screening technologies, including those based on single-nucleotide polymorphisms and copy number variants at the whole-genome level (e.g., genome-wide association studies), transcriptome and DNA methylation sequences. Additionally, comprehensive information on functional genes and genetic variants associated with economically important traits in sheep is provided.

关键词： sheep     high-throughput screening     productive traits     genome-wide studies    

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Improved film evaporator for mechanistic understanding of microwave-induced separation process

Xin Gao, Dandan Shu, Xingang Li, Hong Li

《化学科学与工程前沿（英文）》 2019年 第13卷 第4期   页码 759-771 doi: 10.1007/s11705-019-1816-1

摘要： Microwave-induced film evaporation separation process has been reported recently to separate the polar/nonpolar mixture. However, the efficiency of the separation is still too low for practical applications, which requires further enhancement via different strategies such as optimization design of evaporator structure. In addition the depth understanding of the separation mechanisms is great importance for better utilization of the microwave-induced separation process. To carry out these investigations, a novel microwave-induced falling film evaporation instrument was developed in this paper. The improvement of the enhancement effect of microwave-induced separation was observed based on the improved film evaporator. The systematic experiments on microwave-induced separation with different binary azeotropic mixtures (ethanol-ethyl acetate system and dimethyl carbonate (DMC)-H O system) were conducted based on the new evaporator. For the ethanol-ethyl acetate system, microwave irradiation shift the direction of evaporation separation at higher ethanol content in the starting liquid mixture. Moreover, for DMC-H O system microwave-induced separation process broke through the limitations of the traditional distillation process. The results clearly demonstrated the microwave-induced evaporation separation process could be commendably applied to the separation of binary azeotrope with different dielectric properties. Effects of operating parameters are also investigated to trigger further mechanism understanding on the microwave-induced separation process.

关键词： process intensification     microwave     falling film evaporation     separation     azeotrope    

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Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated

null

《医学前沿（英文）》 2016年 第10卷 第4期   页码 522-526 doi: 10.1007/s11684-016-0485-4

摘要：

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with continuous or recurrent symptoms. A 42-year-old male patient with intermittent diarrhea accompanied by bloody mucopurulent stools was admitted to our hospital. The diagnosis of UC was confirmed by a combination of laboratory examination, colonoscopy, and histological assay. The patient developed herpes zoster in the hospital, which challenged traditional treatments. Therefore, we performed an autologous bone marrow cells to modulate the immune system with his permission. Autologous bone marrow mononuclear cells were collected and injected locally into the bowel mucosa, and subsequently injected systemically through a peripheral vein. After the patient underwent auto bone marrow mononuclear cells transplantations twice, the patient’s symptoms were alleviated. Furthermore, he recovered from hematochezia, and his hypersensitive C reactive protein decreased. Colonoscopy results showed reduced lesions and decreased areas with bleeding and edema in the sigmoid colon and rectum. No recurrence occurred in the subsequent two years, but long-time monitoring is still necessary for the prophylaxis of colorectal cancer.

关键词： autograft     bone marrow stem cells     ulcerative colitis     cell therapy    

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Current understanding and applications of the cold sintering process

Tong Yu, Jiang Cheng, Lu Li, Benshuang Sun, Xujin Bao, Hongtao Zhang

《化学科学与工程前沿（英文）》 2019年 第13卷 第4期   页码 654-664 doi: 10.1007/s11705-019-1832-1

摘要： In traditional ceramic processing techniques, high sintering temperature is necessary to achieve fully dense microstructures. But it can cause various problems including warpage, overfiring, element evaporation, and polymorphic transformation. To overcome these drawbacks, a novel processing technique called “cold sintering process (CSP)” has been explored by Randall et al. CSP enables densification of ceramics at ultra-low temperature (≤300°C) with the assistance of transient aqueous solution and applied pressure. In CSP, the processing conditions including aqueous solution, pressure, temperature, and sintering duration play critical roles in the densification and properties of ceramics, which will be reviewed. The review will also include the applications of CSP in solid-state rechargeable batteries. Finally, the perspectives about CSP is proposed.

关键词： cold sintering process     processing variables     solid-state rechargeable batteries    

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标题 作者 时间 类型 操作

Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

期刊论文

An analytical method for calculating torsional constants for arbitrary complicated thin-walled cross-sections

DU Baisong, GE Yaojun, ZHOU Zheng

期刊论文

Study of base friction simulation tests based on a complicated engineered bridge slope

Liu HE, Guang WU, Hua WANG

期刊论文

The effect of orbital radiation therapy on thyroid-associated orbitopathy complicated with dysthyroid

null

期刊论文

From understanding to designing soundscapes

Jian KANG

期刊论文

整合矿井复杂通风系统的优化改造

张付涛

期刊论文

Air pollution complex: Understanding the sources, formation processes and health effects

Min Shao,Shuxiao Wang,Armistead G. Russell

期刊论文

Fundamental frequency and testing mode of complicated elastic clamped-plate vibration

QI Hongyuan, GUAN Yiduo

期刊论文

Atomistic understanding of interfacial processing mechanism of silicon in water environment: A ReaxFF

期刊论文

Culturomics and metagenomics: In understanding of environmental resistome

Monika Nowrotek, Łukasz Jałowiecki, Monika Harnisz, Grażyna Anna Płaza

期刊论文

Effect of styrene-butadiene-styrene copolymer on the aging resistance of asphalt: An atomistic understanding

期刊论文

Recent advances in understanding genetic variants associated with economically important traits in sheep

Song-Song XU, Meng-Hua LI

期刊论文

Improved film evaporator for mechanistic understanding of microwave-induced separation process

Xin Gao, Dandan Shu, Xingang Li, Hong Li

期刊论文

Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated

null

期刊论文

Current understanding and applications of the cold sintering process

Tong Yu, Jiang Cheng, Lu Li, Benshuang Sun, Xujin Bao, Hongtao Zhang

期刊论文